Creatine: What It Is, How It Is Used and Why Brain Health Research Is Getting Interesting
Creatine has moved a long way from its old reputation as a gym-only supplement.
For years, most people associated it with bodybuilding, strength training and muscle size. This makes sense, because Creatine monohydrate is one of the most researched supplements in sports nutrition, and its strongest evidence is still in exercise performance.
But recently, the conversation around Creatine has widened.
Research has now started to look more closely on Creatine’s role in brain energy, cognitive performance, and neurological health and support.
In this article, we’ll discuss what Creatine is, what it does, it’s current and future benefits, and what dosing creatine looks like now.
What Is Creatine?
Creatine is a compound made naturally in the body from the amino acids arginine, glycine and methionine. It is also found in animal foods such as meat and fish.
Most creatine is stored in skeletal muscle, but it is also found in other tissues, including the brain. Once stored, creatine helps recycle adenosine triphosphate, or ATP. ATP is the body’s immediate energy currency.
Basically, ATP provides quick energy for cells → ATP is used, phosphate group lost and becomes ADP → Creatine helps donate phosphate group back to ADP → ATP is regenerated!
That creatine-phosphocreatine system is especially useful when energy demand rises quickly. In muscle, that might mean sprinting, lifting or repeated high-intensity efforts. In the brain, it may matter when cognitive demand is high or energy availability is under pressure.
This is why creatine sits in an interesting place. It is not just a performance supplement. It is a bioenergetic compound, meaning it is involved in how cells manage and buffer energy.
Why Creatine Is Still Best Known for Exercise
Creatine’s benefits still lie largely in the realm of supporting physical performance.
The Australian Institute of Sport lists creatine monohydrate as a Group A supplement, meaning it has strong evidence for use in specific sporting situations. Its main role is supporting repeated high-intensity efforts, strength and power-based training, and training blocks where performance and adaptation matter.
Exercise types where Creatine tends to be most relevant include:
- resistance training
- sprint work
- repeated high-intensity intervals
- power-based sports
- team sports involving repeated bursts of effort
- training phases where lean mass and strength are priorities
It is less likely to create obvious benefits for low-intensity activity alone. Someone doing gentle walking or occasional yoga may not notice much from creatine. This is because the energy demand is much less.
When we lift heavy weights, sprint, train hard and do explosive workouts, we will notice it more due to a much higher energy demand.
Creatine Monohydrate vs Other Forms
There are many forms of creatine on the market: creatine hydrochloride, buffered creatine, creatine nitrate, creatine ethyl ester and various blended formulas.
I am honestly not opposed to using the other forms, they have their place. Creatine monohydrate is still probably the direction I would go, purely because it’s the form used in most of the research.
The Australian Institute of Sport notes that creatine monohydrate is well absorbed and that there is no clear scientific reason to choose another form over monohydrate for most uses.
The next step is buying Creatine monohydrate that is most pure. In Australia, most commercially available options are suitable and safe. If you want the purest option though, you can look for products that use either Creapure, Purest or OptiCreatine. Some product examples below.
- Creapure – Creapure Creatine by Iceberg Serious Nutrition.
- Purest – Purest Creatine Switch Nutrition.
- OptiCreatine – Noway Creatine by ATP Science.
To avoid overcomplicating it, and just zooming into the benefits of Creatine, start with looking for a product that gives you 3-5g of Creatine per scoop.
Creatine and Brain Energy
The brain is energy hungry. Although it represents only a small percentage of body weight, it uses a large amount of the body’s energy at rest.
This is where creatine research becomes more interesting.
Creatine helps buffer cellular energy. In the brain, that may be relevant during periods of increased demand, such as sleep loss, cognitive stress, ageing, injury or disease states where energy metabolism is altered.
FoundMyFitness (n.d.) highlights this shift well: creatine is no longer being discussed only as a sports supplement. It is also being studied for brain bioenergetics, cognition, sleep deprivation and neurodegenerative conditions.
Pausing here for a second though, The evidence does still show to be more stronger and settled for exercise performance vs brain health. This is not saying it isn’t beneficial, but more that the research is more substantial and available.
Brain-related research is promising, but it’s still developing. Candow et al. (2023) note that dose, duration, age, diet, health status and baseline creatine levels all appear to matter.
What Recent Cognitive Research Suggests
Xu et al. (2024) conducted a systematic review and meta-analysis of 16 randomised controlled trials involving 492 adults. They found that creatine monohydrate supplementation may have benefits for some aspects of cognitive function, particularly memory, attention time and processing speed. The authors also noted that larger, more robust trials are needed.
It does not mean creatine makes everyone smarter. It does not mean every healthy, well-rested adult will feel a dramatic mental boost. It suggests there may be specific cognitive domains and specific contexts where creatine is useful.
From what we can see, Creatine appears have the most measurable impact on a stressed or mentally fatigued brain. This means, we see the highest return on brain-states that are sleep deprived, ageing, have lower dietary creatine intake, or have a higher cognitive workload.
The takeaway is, creatine may be more noticeable when the system is under strain. For someone rested and collected, we’ll see less noticeable improvements.
Creatine and Sleep Deprivation
One of the more interesting newer studies looked at creatine during sleep deprivation.
Gordji-Nejad et al. (2024) gave healthy adults a single high dose of creatine monohydrate, 0.35 grams per kilogram of body weight, during 21 hours of sleep deprivation. The researchers found changes in brain energy markers and improvements in cognitive performance and processing speed compared with placebo.
For an 80 kg adult, 0.35 grams per kilogram is 28 grams of creatine in a single dose. That is much higher than a standard daily maintenance dose. It was used in a controlled research setting, not as a casual daily recommendation.
I would probably not try and consume that bolus of creatine either, it could end up resulting in an immediate trip to the bathroom.
What this really means is, don’t hero dose to get the benefits, spread it out across the day. A simple strategy is often 5g three times daily, or 10g twice daily, it depends on your original tolerance.
Creatine, Ageing and Neurodegenerative Research
FoundMyFitness (n.d.) summarised an early Alzheimer’s disease pilot study where 20 adults with early-stage Alzheimer’s disease took 20 grams of creatine monohydrate per day for 8 weeks, split into two 10 gram doses (see, don’t hero dose it!).
From this study, brain creatine stores increased on average, and several cognitive measures improved, this is amazing.
This study suggests even further than before that higher-dose creatine is capable of increasing brain creatine levels, and the link between creatine and brain-energy research needs more attention.
What was once a supplement just for the gym goer, has almost become a daily wellness or longevity essential. This leads us into the next question.
Who Might Be Most Interested in Creatine?
Creatine is still a very useful tool in your toolkit for people who want support for strength, training capacity or energy-demanding activities.
Creatine may also be super useful for the following
- people doing regular resistance training
- athletes or active people doing repeated high-intensity work
- people rebuilding strength after time away from training
- older adults wanting to support muscle function alongside exercise
- vegetarians or people with low dietary creatine intake
- people with ongoing sleep deprivation or sleep deficits (parenting, anyone?)
- people with high physical or cognitive demands
Please note though, Creatine still works best beside the basics: adequate food, enough protein, progressive training, sleep, hydration and appropriate health care where needed.
Creatine is not a fix all solution, but in fact still a supplemental tool. Foundational health habits should always be covered as well.
Current Dosing Recommendations
For exercise performance and muscle creatine saturation, the standard dosing guidance has not changed dramatically.
Option 1: Loading phase
While less essential to do this now, the thought behind this is saturating muscle stores. This is especially relevant in the strength training or weight lifting area.
The loading approach is around 0.3 grams of creatine monohydrate per kilogram of body weight per day for about 5 days, usually split into 3 to 4 doses with meals.
After loading, a maintenance dose is usually around 3 to 5 grams per day, or about 0.03 grams per kilogram of body weight per day.
Option 2: No loading phase
Many people skip the loading phase and simply take 3 to 5 grams of creatine monohydrate per day.
This can still increase muscle creatine stores over time, but it usually still sufficient for most users.
For general health, training and simplicity, this is often the easiest option. It is cheaper, easier to remember and usually gentler on digestion.
Option 3: Cognitive demand dosing
There is no true exact number for this, so the optimal dose on increasing brain creatine is not clear.
Fabiano and Candow (2025) argue that brain-focused creatine research often uses higher dosing than standard sports nutrition protocols, but the ideal dose is still not clear. The practical approach here would be to split this up twice or three times daily (so 10g or 5g per dose per day).
Of course, if you have any pre-existing kidney or complex health issues, speaking to a health professional first is important before doing this.
Timing: When Should You Take Creatine?
Creatine works by increasing tissue creatine stores over time. It is not like caffeine, where the timing is tightly linked to an immediate stimulant effect.
The Australian Institute of Sport notes that creatine uptake may be supported when taken with meals containing carbohydrate and protein. Taking it after training with a normal post-exercise meal is also a practical habit for many people.
Some good times to fit creatine into your schedule is with breakfast, with lunch, before training, or simply mixed into a smoothie.
If creatine upsets your stomach, try taking it with food, using a smaller dose, or skipping the loading phase.
Common Creatine Myths
Myth 1: Creatine is a steroid
Creatine is not an anabolic steroid. It has a completely different structure and function. It is made naturally in the body and found in food.
Myth 2: Creatine is only for bodybuilders
Creatine is popular in bodybuilding, but its use is broader than that. It may support strength, power, sprint performance, training volume, older-adult muscle function and emerging areas of brain-energy research.
Myth 3: More creatine is always better
Higher doses may be used in specific research settings (such as sleep deprivation or high cognitive load, but for everyday use, 3 to 5 grams per day is still the most practical baseline for most healthy adults.
Myth 4: Creatine causes fat gain
Creatine can increase body weight in some people, often through increased water stored with muscle creatine. That is not the same as fat gain.
Myth 5: Creatine damages kidneys in healthy people
Antonio et al. (2021) note that creatine is generally well tolerated at recommended doses in healthy people. However, people with kidney disease, abnormal kidney markers or complex medical situations should get professional guidance first.
The Takeaway
Creatine monohydrate remains one of the most evidence-backed supplements for strength, power and repeated high-intensity exercise.
What has changed is the conversation around it.
Creatine is now being studied as a broader energy-support compound, particularly for the brain. The newer research into cognition, sleep deprivation, ageing and neurodegenerative conditions is promising, but it is not as settled as the exercise-performance research.
For most healthy adults, the practical starting point is still simple: creatine monohydrate, 3 to 5 grams per day, taken consistently. Loading can be useful when faster muscle saturation is desired, but it is not essential.
The bigger picture still matters. Creatine works best when it sits beside good food, enough protein, regular training, sleep and sensible health care.
If you are unsure whether creatine fits your goals, Stephen can help you look at the full picture: nutrition, training, lifestyle, energy, sleep and whether supplementation is likely to be useful for your situation.
FAQ
What is creatine used for?
Creatine is best known for supporting strength, power, repeated high-intensity exercise and training adaptation. It is also being researched for brain energy, cognition, sleep deprivation and ageing.
What is the best form of creatine?
Creatine monohydrate is the best-supported form and is usually the most practical choice.
How much creatine should I take?
A common daily dose is 3 to 5 grams of creatine monohydrate. A loading phase of around 20 grams per day for about 5 days can saturate muscle stores faster, followed by 3 to 5 grams per day.
Do I need to load creatine?
No. Loading is optional. Taking 3 to 5 grams per day without loading can still increase muscle creatine stores over time.
Can creatine support brain health?
Creatine may support aspects of brain energy metabolism, and research suggests possible benefits for memory, attention time and processing speed in some adults. The evidence is promising but still developing.
Are higher doses needed for brain benefits?
Possibly, but this is not settled. Some brain-focused studies use higher doses than standard sports nutrition protocols, but these are research settings rather than general public dosing advice.
Is creatine safe?
Creatine monohydrate is generally well tolerated in healthy people when used at recommended doses. People with kidney disease, complex medical conditions, pregnancy, breastfeeding or medication concerns should seek professional guidance first.
Does creatine cause weight gain?
It can increase scale weight for some people, often because creatine increases water stored inside muscle. This is not the same as gaining body fat.
References
Australian Institute of Sport. (n.d.). Creatine: How and when do I use it? Australian Sports Commission. https://www.ausport.gov.au/ais/nutrition/supplements/group_a/performance-supplements2/creatine/how-and-when-do-i-use-it
Antonio, J., Candow, D. G., Forbes, S. C., Gualano, B., Jagim, A. R., Kreider, R. B., Rawson, E. S., Smith-Ryan, A. E., VanDusseldorp, T. A., Willoughby, D. S., & Ziegenfuss, T. N. (2021). Common questions and misconceptions about creatine supplementation: What does the scientific evidence really show? Journal of the International Society of Sports Nutrition, 18, Article 13. https://doi.org/10.1186/s12970-021-00412-w
Candow, D. G., Forbes, S. C., Ostojic, S. M., Prokopidis, K., Stock, M. S., Harmon, K. K., & Faulkner, P. (2023). “Heads up” for creatine supplementation and its potential applications for brain health and function. Sports Medicine, 53(Suppl. 1), 49-65. https://doi.org/10.1007/s40279-023-01870-9
Fabiano, N., & Candow, D. (2025). Creatine supplementation: More is likely better for brain bioenergetics, health and function. Journal of Psychiatry and Brain Science, 10(4), Article e250006. https://doi.org/10.20900/jpbs.20250006
FoundMyFitness. (n.d.). Creatine. https://www.foundmyfitness.com/topics/creatine
Gordji-Nejad, A., Matusch, A., Kleedörfer, S., Patel, H. J., Drzezga, A., Elmenhorst, D., & Bauer, A. (2024). Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation. Scientific Reports, 14, Article 4937. https://doi.org/10.1038/s41598-024-54249-9
Xu, C., Bi, S., Zhang, W., & Luo, L. (2024). The effects of creatine supplementation on cognitive function in adults: A systematic review and meta-analysis. Frontiers in Nutrition, 11, Article 1424972. https://doi.org/10.3389/fnut.2024.1424972

